期刊
ANNUAL REVIEW OF PHYSIOLOGY, VOL 74
卷 74, 期 -, 页码 87-105出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-physiol-020911-153233
关键词
osteocalcin; serotonin; bone mass accrual; energy metabolism; reproduction
类别
资金
- NICHD NIH HHS [R01 HD065439] Funding Source: Medline
Classical studies of vertebrate physiology have usually been confined to a given organ or cell type. The use of mouse genetics has changed this approach and has rejuvenated the concept of a whole-body study of physiology. One physiological system that has been profoundly influenced by mouse genetics is skeletal physiology. Indeed, genetic approaches have identified several unexpected organs that affect bone physiology. These new links have begun to provide a plausible explanation for the evolutionary involvement of hormones such as leptin with bone physiology. These genetic approaches have also revealed bone as a true endocrine organ capable of regulating energy metabolism and reproduction. Collectively, the body of work discussed below illustrates a new and unconventional role for bone in mammalian physiology.
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