期刊
ANNUAL REVIEW OF PHYSIOLOGY, VOL 74
卷 74, 期 -, 页码 325-349出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-physiol-020911-153225
关键词
pendrin; purinergic signaling; serine protease; hypertension; potassium; sodium; acid-base
类别
资金
- NIDDK NIH HHS [R01 DK064324, R01 DK074754, DK74754, DK64324] Funding Source: Medline
The distal nephron plays a critical role in the renal control of homeostasis. Until very recently most studies focused on the control of Na+, K+, and water balance by principal cells of the collecting duct and the regulation of solute and water by hormones from the renin-angiotensin-aldosterone system and by antidiuretic hormone. However, recent studies have revealed the unexpected importance of renal intercalated cells, a subtype of cells present in the connecting tubule and collecting ducts. Such cells were thought initially to be involved exclusively in acid-base regulation. However, it is clear now that intercalated cells absorb NaCl and K+ and hence may participate in the regulation of blood pressure and potassium balance. The second paradigm-challenging concept we highlight is the emerging importance of local paracrine factors that play a critical role in the renal control of water and electrolyte balance.
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