期刊
ANNUAL REVIEW OF PHYSIOLOGY, VOL 73
卷 73, 期 -, 页码 115-134出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-physiol-012110-142203
关键词
desiccation tolerance; anhydrobiosis; osmolytes; trehalose; intrinsically disordered proteins
类别
资金
- NIDDK NIH HHS [2R01DK046270-14A1] Funding Source: Medline
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK046270] Funding Source: NIH RePORTER
Late embryogenesis abundant (LEA) proteins are extremely hydrophilic proteins that were first identified in land plants. Intracellular accumulation is tightly correlated with acquisition of desiccation tolerance, and data support their capacity to stabilize other proteins and membranes during drying, especially in the presence of sugars like trehalose. Exciting reports now show that LEA proteins are not restricted to plants; multiple forms are expressed in desiccation-tolerant animals from at least four phyla. We evaluate here the expression, subcellular localization, biochemical properties, and potential functions of LEA proteins in animal species during water stress. LEA proteins are intrinsically unstructured in aqueous solution, but surprisingly, many assume their native conformation during drying. They are targeted to multiple cellular locations, including mitochondria, and evidence supports that LEA proteins stabilize vitrified sugar glasses thought to be important in the dried state. More in vivo experimentation will be necessary to fully unravel the multiple functional properties of these macromolecules (luring water stress.
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