期刊
ANNUAL REVIEW OF PHYSIOLOGY, VOL 73
卷 73, 期 -, 页码 283-309出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-physiol-012110-142150
关键词
paracellular permeability; barrier function; claudin; occludin; ZO-1
类别
资金
- NCI NIH HHS [P30CA14599, P30 CA014599] Funding Source: Medline
- NCRR NIH HHS [UL1RR024999, UL1 RR024999] Funding Source: Medline
- NIDDK NIH HHS [F32 DK082134, R01 DK061931, R01DK68271, P01DK067887, R01DK61931, K08 DK088953, P30DK042086, F32DK082134, P01 DK067887, P30 DK042086, R01 DK068271, K08DK088953] Funding Source: Medline
- NIGMS NIH HHS [T32 GM007281, 5T32GM007281] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [P30CA014599] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [UL1RR024999] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK068271, P01DK067887, P30DK042086, F32DK082134, K08DK088953, R01DK061931] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [T32GM007281] Funding Source: NIH RePORTER
Tissue barriers that restrict passage of liquids, ions, and larger solutes are essential for the development of multicellular organisms. In simple organisms this allows distinct cell types to interface with the external environment. In more complex species, the diversity of cell types capable of forming barriers increases dramatically. Although the plasma membranes of these barrier-forming cells prevent flux of most hydrophilic solutes, the paracellular, or shunt, pathway between cells must also be sealed. This function is accomplished in vertebrates by the zonula occludens, or tight junction. The tight junction barrier is not absolute but is selectively permeable and is able to discriminate between solutes on the basis of size and charge. Many tight junction components have been identified over the past 20 years, and recent progress has provided new insights into the proteins and interactions that regulate structure and function. This review presents these data in a historical context and proposes an integrated model in which dynamic regulation of tight junction protein interactions determines barrier function.
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