期刊
ANNUAL REVIEW OF PHYSIOLOGY, VOL 73
卷 73, 期 -, 页码 527-545出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-physiol-012110-142305
关键词
venous thrombosis; tissue factor; microvesicle; hypoxia-inducible factor-1 (HIF-1); P-selectin; endothelium
类别
资金
- NHLBI NIH HHS [P01 HL046703, R01 HL085646] Funding Source: Medline
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL085646, P01HL046703] Funding Source: NIH RePORTER
This review focuses on the role of the venous valves in the genesis of thrombus formation in venous thromboembolic disease (VTE). Clinical VTE and the evidence for the valvular origin of venous thrombosis are reviewed. Virchow's triad is then used as a framework for discussion to approach the question posed regarding the link between venous valvular stasis associated hypoxia and thrombosis. Thus, the effects of blood flow stasis, hypercoagulability of blood, and the characteristics of the vessel wall within the venous valvular sinus are assessed in turn.
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