期刊
ANNUAL REVIEW OF PHYSIOLOGY
卷 72, 期 -, 页码 463-493出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-physiol-021909-135833
关键词
signal transduction; endothelial barrier function; adherens junctions; albumin transport; caveolin-1
类别
资金
- NHLBI NIH HHS [R01 HL 45638, P01 HL 60678] Funding Source: Medline
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [P01HL060678, R01HL045638] Funding Source: NIH RePORTER
The endothelium functions as a semipermeable barrier regulating tissue fluid homeostasis and transmigration of leukocytes and providing essential nutrients across the vessel wall. Transport of plasma proteins and solutes across the endothelium involves two different routes: one transcellular, via caveolae-mediated vesicular transport, and the other paracellular, through interendothelial junctions. The permeability of the endothelial barrier is an exquisitely regulated process in the resting state and in response to extracellular stimuli and mediators. The focus of this review is to provide a comprehensive overview of molecular and signaling mechanisms regulating endothelial barrier permeability with emphasis on the cross-talk between paracellular and transcellular transport pathways.
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