期刊
ANNUAL REVIEW OF PHYSIOLOGY
卷 72, 期 -, 页码 579-603出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-physiol-073109-130051
关键词
transcriptional circuit; temperature compensation; singularity; artificial circuit
类别
资金
- RIKEN Center for Developmental Biology (CDB)
- Genomic Science Center, RIKEN
- National Project on Protein Structural and Functional Analyses
- Japanese Ministry of Education, Culture, Sports,Science and Technology
- KAKENHI
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- New Energy and Industrial Technology Development Organization (NEDO)
- NEDO
- Institute of Physical and Chemical Research
- Uehara Memorial Foundation
- Japan Society for the Promotion of Science for Young Scientists [17-4169]
Systems biology is a natural extension of molecular biology; it can be defined as biology after identification of key gene(s). Systems-biological research is a multistage process beginning with (a) the comprehensive identification and (b) quantitative analysis of individual system components and their networked interactions, which lead to the ability to (c) control existing systems toward the desired state and (d) design new ones based on an understanding of the underlying structure and dynamical principles. In this review, we use the mammalian circadian clock as a model system and describe the application of systems-biological approaches to fundamental problems in this model. This application has allowed the identification of transcriptional/posttranscriptional circuits, the discovery of a temperature-insensitive period-determining process, and the discovery of desynchronization of individual clock cells underlying the singularity behavior of mammalian clocks.
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