期刊
ANNUAL REVIEW OF PHYSIOLOGY
卷 70, 期 -, 页码 459-486出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev.physiol.70.113006.100702
关键词
innate defense; MUC5B; AIUC5AC; hypersecretory disease
类别
资金
- Biotechnology and Biological Sciences Research Council Funding Source: Medline
- Wellcome Trust Funding Source: Medline
The airways mucus gel performs a critical function in defending the respiratory tract against pathogenic and environmental challenges. In normal physiology, the secreted mucins, in particular the polymeric mucins MUC5AC and MUM, provide the organizing framework of the airways mucus gel and are major contributors to its theological properties. However, overproduction of mucins is an important factor in the morbidity and mortality of chronic airways disease (e.g., asthma, cystic fibrosis, and chronic obstructive pulmonary disease). The roles of these enormous, multifunctional, O-linked glycoproteins in health and disease are discussed.
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