期刊
ANNUAL REVIEW OF PHYSIOLOGY
卷 70, 期 -, 页码 431-457出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev.physiol.70.113006.100659
关键词
MUC1; MUC4; MUC16; cancer; respiratory disease; signaling
类别
资金
- NCI NIH HHS [P50CA116201, R01CA118944, R01CA64389] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA118944, R01CA064389, P50CA116201] Funding Source: NIH RePORTER
Cell surface mucins are large transmembrane glycoproteins involved in diverse functions ranging from shielding the air-way epithelium against pathogenic infection to regulating cellular signaling and transcription. Although hampered by the relatively recent characterization of cell surface mucins and the difficulties inherent in working with molecules of their size, numerous studies have placed the tethered mucins in the thick of normal and diseased lung physiology. This review focuses on the three best-characterized cell surface mucins expressed in the respiratory tract: MUC1, MUC4, and MUC16.
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