期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 15, 期 22, 页码 5095-5099出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2005.06.083
关键词
structure based design; 6-anilinoindazoles; c-Jun N-terminal kinase-3; JNK3 inhibitors
The structure-based design and synthesis of a new series of c-Jun N-terminal kinase-3 inhibitors with selectivity against JNK1 and p38 alpha is reported. The novel series of substituted 6-anilinoindazoles were designed based on a combination of hits from high throughput screening and X-ray crystal structure information of the compounds crystallized into the JNK3 ATP binding active site. (c) 2005 Elsevier Ltd. All rights reserved.
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