期刊
JOURNAL OF IMMUNOLOGY
卷 175, 期 10, 页码 6344-6351出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.175.10.6344
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资金
- NCI NIH HHS [R01CA47724] Funding Source: Medline
- NIAID NIH HHS [R37AI28973] Funding Source: Medline
- NIAMS NIH HHS [K08AR01996, R21AR48037] Funding Source: Medline
Individual CM-restricted T cells can recognize either endogenous or foreign lipid Ags, but the extent to which the same CD1-restricted TCR can react to both self and microbial lipids is unknown. In this study, we have identified CD1a-, CD1b-, and CD1c-restricted T cells from normal human donors that induce cytolysis and secrete copious IFN-gamma in response to self-CD1 expressed on monocyte-derived dendritic cells. Remarkably, microbial Ags presented by CD1 are even more potent agonists for these same T cells. The alpha beta T cell receptors from such clones are diverse and confer specificity for both self-CD1 and foreign lipid Ags. The dual reactivity of these CD1-restricted cells suggests that the capacity for rapid responses to inflammatory stimuli without memory coexists with the capacity for strong Ag-specific responses and the generation of memory in vivo.
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