期刊
FEMS MICROBIOLOGY LETTERS
卷 252, 期 2, 页码 327-335出版社
OXFORD UNIV PRESS
DOI: 10.1016/j.femsle.2005.09.043
关键词
iron; Burkholderia pseudomallei; B. mallei
类别
资金
- NIAID NIH HHS [R01AI50565, R01AI056006] Funding Source: Medline
Burkholderia pseudomallei and B. mallei are the causative agents of melioidosis and glanders, respectively. As iron regulation of gene expression is common in bacteria, in the present studies, we have used microarray analysis to examine the effects of growth in different iron concentrations on the regulation of gene expression in B. pseudomallei and B. mallei. Gene expression profiles for these two bacterial species were similar under high and low iron growth conditions irrespective of growth phase. Growth in low iron led to reduced expression of genes encoding most respiratory metabolic systems and proteins of putative function, such as NADH-dehydrogenases, cytochrome oxidases, and ATP-synthases. In contrast, genes encoding siderophore-mediated iron transport, heme-hemin receptors, and a variety of metabolic enzymes for alternative metabolism were induced under low iron conditions. The overall gene expression profiles suggest that B. pseudomallei and B. mallei are able to adapt to the iron-restricted conditions in the host environment by up-regulating an iron-acquisition system and by using alternative metabolic pathways for energy production. The observations relative to the induction of specific metabolic enzymes during bacterial growth under low iron conditions warrants further experimentation. (c) 2005 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.
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