期刊
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 53, 2013
卷 53, 期 -, 页码 17-36出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-pharmtox-010611-134648
关键词
hepcidin; hemochromatosis; transferrin; DMT1; NTBI
资金
- NIDA NIH HHS [R03 DA027030, R21 DA025573] Funding Source: Medline
- NIDDK NIH HHS [R01 DK064750, RC1 DK086774] Funding Source: Medline
- NIEHS NIH HHS [R01 ES014638, T32 ES016645] Funding Source: Medline
Elucidating the molecular basis for the regulation of iron uptake, storage, and distribution is necessary to understand iron homeostasis. Pharmacological tools are emerging to identify and distinguish among different iron transport pathways. Stimulatory or inhibitory small molecules with effects on iron uptake can help characterize the mechanistic elements of iron transport and the roles of the transporters involved in these processes. In particular, iron chelators can serve as potential pharmacological tools to alleviate diseases of iron overload. This review focuses on the pharmacology of iron transport, introducing iron transport membrane proteins and known inhibitors.
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