期刊
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY
卷 48, 期 -, 页码 171-197出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev.pharmtox.48.121806.154841
关键词
leukocytes; chemotaxis; disease; drug discovery
资金
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R37AI040618] Funding Source: NIH RePORTER
- Associazione Italiana per la Ricerca sul Cancro Funding Source: Custom
- NIAID NIH HHS [R37 AI040618] Funding Source: Medline
The chemokine system coordinates leukocyte migration in immunity and inflammation and is implicated in the pathogenesis of many human diseases. Although several successful strategies have been identified to develop drugs targeting chemokines and their receptors, this has not yet resulted in many new therapeutics. This is likely due to a complexity of the chemokine system, which was not initially appreciated, that is characterized by redundancy, pleiotropy, and differences among species. Nevertheless, our understanding of chemokine biology is continuing to grow and several promising drugs are currently being tested in late-stage clinical trials. In this review, we examine the role of chemokines in health and diseases and discuss strategies to target the chemokine system.
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