期刊
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY
卷 48, 期 -, 页码 653-683出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev.pharmtox.48.113006.094715
关键词
pharmacometabolomics; metabolomic signatures; HPLC; mass spectroscopy; NMR; electrochemical array detection
资金
- NCI NIH HHS [R01 CA 102536, R01 CA102536] Funding Source: Medline
- NIA NIH HHS [R01 AG 25872, R01 AG 28996, R01 AG025872, R01 AG028996] Funding Source: Medline
- NIGMS NIH HHS [R01 GM 28157, U01 GM 61388, R24 GM 078233] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA102536] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM028157, R24GM078233, U01GM061388] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG025872, R01AG028996] Funding Source: NIH RePORTER
Metabolomics is the study of metabolism at the global level. This rapidly developing new discipline has important potential implications for pharmacologic science. The concept that metabolic state is representative of the overall physiologic status of the organism lies at the heart of metabolomics. Metabolomic studies capture global biochemical events by assaying thousands of small molecules in cells, tissues, organs, or biological fluids-followed by the application of informatic techniques to define metabolomic signatures. Metabolomic studies can lead to enhanced understanding of disease mechanisms and to new diagnostic markers as well as enhanced understanding of mechanisms for drug or xenobiotic effect and increased ability to predict individual variation in drug response phenotypes (pharmacometabolomics). This review outlines the conceptual basis for metabolomics as well as analytical and informatic techniques used to study the metabolome and to define metabolomic signatures. It also highlights potential metabolomic applications to pharmacology and clinical pharmacology.
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