期刊
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY
卷 48, 期 -, 页码 495-535出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev.pharmtox.48.080907.180426
关键词
cisplatin; carboplatin; resistance; cellular accumulation; drug uptake
资金
- NATIONAL CANCER INSTITUTE [Z01BC010830, ZIABC010830] Funding Source: NIH RePORTER
- Intramural NIH HHS Funding Source: Medline
The platinum (Pt) drugs cisplatin and carboplatin are heavily employed in chemotherapy regimens; however, similar to other classes of drugs, a number of intrinsic and acquired resistance mechanisms hamper their effectiveness. The method by which Pt drugs enter cells has traditionally been attributed to simple passive diffusion. However, recent evidence suggests a number of active uptake and efflux mechanisms are at play, and altered regulation of these transporters is responsible for the reduced accumulation of drug in resistant cells. This review suggests a model that helps reconcile the disparate literature by describing multiple pathways for Pt-containing drugs into and out of the cell.
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