期刊
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY
卷 48, 期 -, 页码 359-391出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev.pharmtox.48.121506.124841
关键词
signaling molecules; caveolin; myocardial ischemia; pulmonary hypertension
资金
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [K99HL091061, P01HL066941, R00HL091061] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM066232] Funding Source: NIH RePORTER
- NHLBI NIH HHS [R00 HL091061, K99 HL091061, HL 66941, P01 HL066941] Funding Source: Medline
- NIGMS NIH HHS [R01 GM066232, R01 GM066232-06, GM 66232] Funding Source: Medline
Caveolae, a subset of membrane (lipid) rafts, are flask-like invaginations of the plasma membrane that contain caveolin proteins, which serve as organizing centers for cellular signal transduction. Caveolins (-1, -2, and -3) have cytoplasmic N and C termini, palmitolylation sites, and a scaffolding domain that facilitates interaction and organization of signaling molecules so as to help provide coordinated and efficient signal transduction. Such signaling components include upstream entities (e.g., G protein-coupled receptors (GPCRs), receptor tyrosine kinases, and steroid hormone receptors) and downstream components (e.g., heterotrimeric and low-molecular-weight G proteins, effector enzymes, and ion channels). Diseases associated with aberrant signaling may result in altered localization or expression of signaling proteins in caveolae. Caveolin-knockout mice have numerous abnormalities, some of which may reflect the impact of total body knockout throughout the life span. This review provides a general overview of caveolins and caveolae, signaling molecules that localize to caveolae, the role of caveolac/caveolin in cardiac and pulmonary pathophysiology, pharmacologic implications of caveolar localization of signaling molecules, and the possibility that caveolae might serve as a therapeutic target.
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