期刊
ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 7
卷 7, 期 -, 页码 353-384出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-pathol-011811-132458
关键词
Mycobacterium tuberculosis; granuloma; phagosome maturation; innate immunity; acquired immunity; immune evasion
类别
资金
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R56AI084041, R01AI084041, R01AI090928, R01AI087682, R01AI051242] Funding Source: NIH RePORTER
- NIAID NIH HHS [AI090928, R01 AI051242, R01 AI087682, AI084041] Funding Source: Medline
Despite the development of potentially curative chemotherapy, tuberculosis (TB) continues to cause increasing worldwide morbidity and is a leading cause of human mortality in the developing world. Recent advances in bacterial molecular genetics, immunology, and human genetics have yielded insight into the molecular determinants of virulence, the immune responses that are essential for restricting progressive disease, and the determinants of immunopathology in TB. Despite these advances, a large knowledge gap still exists that limits the development and testing of new interventions, including novel drugs and efficacious vaccines. This review focuses on our current knowledge of TB pathogenesis and immunity that has been derived from in vitro and in vivo studies. In addition, it highlights topics that need to be better understood to provide improved means of controlling TB worldwide.
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