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Shunya Arai et al.
BLOOD (2011)
Requirement for Dot1l in murine postnatal hematopoiesis and leukemogenesis by MLL translocation
Stephanie Y. Jo et al.
BLOOD (2011)
DOT1L, the H3K79 methyltransferase, is required for MLL-AF9-mediated leukemogenesis
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BLOOD (2011)
MLL-AF9 and MLL-ENL alter the dynamic association of transcriptional regulators with genes critical for leukemia
Sara C. Monroe et al.
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The leukemogenic AF4-MLL fusion protein causes P-TEFb kinase activation and altered epigenetic signatures
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D. Williams Parsons et al.
SCIENCE (2011)
Expression of HOXB genes is significantly different in acute myeloid leukemia with a partial tandem duplication of MLL vs. a MLL translocation: a cross-laboratory study
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CANCER GENETICS (2011)
Gene expression profiling-based dissection of MLL translocated and MLL germline acute lymphoblastic leukemia in infants
Ronald W. Stam et al.
BLOOD (2010)
The AF4.MLL fusion protein is capable of inducing ALL in mice without requirement of MLL.AF4
Adelheid Bursen et al.
BLOOD (2010)
FLT3 as a therapeutic target in AML: still challenging after all these years
Thomas Kindler et al.
BLOOD (2010)
A Higher-Order Complex Containing AF4 and ENL Family Proteins with P-TEFb Facilitates Oncogenic and Physiologic MLL-Dependent Transcription
Akihiko Yokoyama et al.
CANCER CELL (2010)
MLL-AF9-Induced Leukemogenesis Requires Coexpression of the Wild-Type Mll Allele
Austin T. Thiel et al.
CANCER CELL (2010)
The PAF Complex Synergizes with MLL Fusion Proteins at HOX Loci to Promote Leukemogenesis
Andrew G. Muntean et al.
CANCER CELL (2010)
GSK-3 Promotes Conditional Association of CREB and Its Coactivators with MEIS1 to Facilitate HOX-Mediated Transcription and Oncogenesis
Zhong Wang et al.
CANCER CELL (2010)
Histone H3 Lysine 79 Methyltransferase Dot1 Is Required for Immortalization by MLL Oncogenes
Ming-Jin Chang et al.
CANCER RESEARCH (2010)
Pro Isomerization in MLL1 PHD3-Bromo Cassette Connects H3K4me Readout to CyP33 and HDAC-Mediated Repression
Zhanxin Wang et al.
CELL (2010)
CDK Inhibitors: From the Bench to Clinical Trials
Flavio Rizzolio et al.
CURRENT DRUG TARGETS (2010)
Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom)
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GENES & DEVELOPMENT (2010)
Molecular Basis of the Mixed Lineage Leukemia-Menin Interaction IMPLICATIONS FOR TARGETING MIXED LINEAGE LEUKEMIAS
Jolanta Grembecka et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Binding of the MLL PHD3 Finger to Histone H3K4me3 Is Required for MLL-Dependent Gene Transcription
Pei-Yun Chang et al.
JOURNAL OF MOLECULAR BIOLOGY (2010)
Flavopiridol, the First Cyclin-Dependent Kinase Inhibitor: Recent Advances in Combination Chemotherapy
L. -M. Wang et al.
MINI-REVIEWS IN MEDICINAL CHEMISTRY (2010)
Multiple Interactions Recruit MLL1 and MLL1 Fusion Proteins to the HOXA9 Locus in Leukemogenesis
Thomas A. Milne et al.
MOLECULAR CELL (2010)
AFF4, a Component of the ELL/P-TEFb Elongation Complex and a Shared Subunit of MLL Chimeras, Can Link Transcription Elongation to Leukemia
Chengqi Lin et al.
MOLECULAR CELL (2010)
Leukemic fusion genes MLL/AF4 and AML1/MTG8 support leukemic self-renewal by controlling expression of the telomerase subunit TERT
A. Gessner et al.
LEUKEMIA (2010)
Phosphorylation of MLL by ATR is required for execution of mammalian S-phase checkpoint
Han Liu et al.
NATURE (2010)
Structure of the MLL CXXC domain-DNA complex and its functional role in MLL-AF9 leukemia
Tomasz Cierpicki et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2010)
The Wnt/β-Catenin Pathway Is Required for the Development of Leukemia Stem Cells in AML
Yingzi Wang et al.
SCIENCE (2010)
Licensed to elongate: a molecular mechanism for MLL-based leukaemogenesis
Man Mohan et al.
NATURE REVIEWS CANCER (2010)
Regulation of mir-196b by MLL and its overexpression by MLL fusions contributes to immortalization
Relja Popovic et al.
BLOOD (2009)
Hierarchical Maintenance of MLL Myeloid Leukemia Stem Cells Employs a Transcriptional Program Shared with Embryonic Rather Than Adult Stem Cells
Tim C. P. Somervaille et al.
CELL STEM CELL (2009)
Regulation of Hox Gene Activity by Transcriptional Elongation in Drosophila
Vivek S. Chopra et al.
CURRENT BIOLOGY (2009)
MLL Associates with Telomeres and Regulates Telomeric Repeat-Containing RNA Transcription
Corrado Caslini et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
New insights to the MLL recombinome of acute leukemias
C. Meyer et al.
LEUKEMIA (2009)
Alterations of the CxxC domain preclude oncogenic activation of mixed-lineage leukemia 2
C. Bach et al.
ONCOGENE (2009)
Misguided Transcriptional Elongation Causes Mixed Lineage Leukemia
Dorothee Mueller et al.
PLOS BIOLOGY (2009)
The PHD fingers of MLL block MLL fusion protein-mediated transformation
Andrew G. Muntean et al.
BLOOD (2008)
DNA hypermethylation and epigenetic silencing of the tumor suppressor gene, SLC5A8, in acute myeloid leukemia with the MLL partial tandem duplication
Susan P. Whitman et al.
BLOOD (2008)
Menin critically links MLL proteins with LEDGE on cancer-associated target genes
Akihiko Yokoyama et al.
CANCER CELL (2008)
Loss of MLL PHD finger 3 is necessary for MLL-ENL-induced hematopoietic stem cell immortalization
Jing Chen et al.
CANCER RESEARCH (2008)
MLL protects CpG clusters from methylation within the Hoxa9 gene, maintaining transcript expression
Frank E. Erfurth et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
RNA polymerase is poised for activation across the genome
Ginger W. Muse et al.
NATURE GENETICS (2007)
MLL translocations, histone modifications and leukaemia stem-cell development
Andrei V. Krivtsov et al.
NATURE REVIEWS CANCER (2007)
Bimodal degradation of MLL by SCFSkp2 and APCCdc20 assures cell cycle execution:: a critical regulatory circuit lost in leukemogenic MLL fusions
Han Liu et al.
GENES & DEVELOPMENT (2007)
Hox genes in hematopoiesis and leukemogenesis
B. Argiropoulos et al.
ONCOGENE (2007)
Protein arginine-methyltransferase-dependent oncogenesis
Ngai Cheung et al.
NATURE CELL BIOLOGY (2007)
MII has a critical role in fetal and adult hematopoietic stem cell self-renewal
Kathryn A. McMahon et al.
CELL STEM CELL (2007)
Unique and independent roles for MLL in adult hematopoietic stem cells and progenitors
Craig D. Jude et al.
CELL STEM CELL (2007)
Interaction of MLL amino terminal sequences with menin is required for transformation
Corrado Caslini et al.
CANCER RESEARCH (2007)
E2F activation of S phase promoters via association with HCF-1 and the MLL family of histone H3K4 methyltransferases
Shweta Tyagi et al.
MOLECULAR CELL (2007)
The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling
Emmanuelle Bitoun et al.
HUMAN MOLECULAR GENETICS (2007)
The MLL partial tandem duplication in acute myeloid leukaemia
Jorg Basecke et al.
BRITISH JOURNAL OF HAEMATOLOGY (2006)
Solution structure of the nonmethyl-CpG-binding CXXC domain of the leukaemia-associated MLL histone methyltransferase
Mark D. Allen et al.
EMBO JOURNAL (2006)
MII partial tandem duplication induces aberrant Hox expression in vivo via specific epigenetic alterations
Adrienne M. Dorrance et al.
JOURNAL OF CLINICAL INVESTIGATION (2006)
Proteolysis of MLL family proteins is essential for Taspase1-orchestrated cell cycle progression
Shugaku Takeda et al.
GENES & DEVELOPMENT (2006)
Molecular regulation of H3K4 trimethylation by ASH2L, a shared subunit of MLL complexes
Melissa M. Steward et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2006)
Regulation of MLL1 H3K4 methyltransferase activity by its core components
Yali Dou et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2006)
A bivalent chromatin structure marks key developmental genes in embryonic stem cells
BE Bernstein et al.
CELL (2006)
Del(5q) and MLL amplification in homogeneously staining region in acute myeloblastic leukemia:: a recurrent cytogenetic association
A Herry et al.
ANNALS OF HEMATOLOGY (2006)
Leukemogenic MLL fusion proteins bind across a broad region of the Hox a9 locus, promoting transcription and multiple histone modifications
TA Milne et al.
CANCER RESEARCH (2005)
Eater, a transmembrane protein mediating phagocytosis of bacterial pathogens in Drosophila
C Kocks et al.
CELL (2005)
The menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesis
A Yokoyama et al.
CELL (2005)
The MLL fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B (p27kip1) expression
ZB Xia et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
The eleven-nineteen-leukemia protein ENL connects nuclear MLL fusion partners with chromatin
DT Zeisig et al.
ONCOGENE (2005)
Physical association and coordinate function of the H3K4 methyltransferase MLL1 and the H4K16 acetyltransferase MOF
YL Dou et al.
CELL (2005)
WDR5 associates with histone H3 methylated at K4 and is essential for H3K4 methylation and vertebrate development
J Wysocka et al.
CELL (2005)
hDOT1L links histone methylation to leukemogenesis
Y Okada et al.
CELL (2005)
Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors
TA Milne et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
MLL: a histone methyltransferase disrupted in leukemia
JL Hess
TRENDS IN MOLECULAR MEDICINE (2004)
Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression
A Yokoyama et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Ammonium effects on colonic Cl- secretion: anomalous mole fraction behavior
RT Worrell et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2004)
Methylenetetrahydrofolate reductase polymorphism (C677T), hyperhomocysteinemia, and risk of ischemic cardiovascular disease and venous thromboembolism:: prospective and case-control studies from the Copenhagen City Heart Study
J Frederiksen et al.
BLOOD (2004)
Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization
BB Zeisig et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Expression analyses identify MLL as a prominent target of 11q23 amplification and support an etiologic role for MLL gain of function in myeloid malignancies
B Poppe et al.
BLOOD (2004)
Epigenetic regulation of cellular memory by the polycomb and trithorax group proteins
L Ringrose et al.
ANNUAL REVIEW OF GENETICS (2004)
Taspase1:: A threonine aspartase required for cleavage of MLL and proper HOX gene expression
JJD Hsieh et al.
CELL (2003)
Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9
PM Ayton et al.
GENES & DEVELOPMENT (2003)
The Rtf1 component of the Paf1 transcriptional elongation complex is required for ubiquitination of histone H2B
HH Ng et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Dimerization of MLL fusion proteins immortalizes hematopoietic cells
ME Martin et al.
CANCER CELL (2003)
Aberrant expression of HOXA9, DEK, CBL and CSF1R in acute myeloid leukemia
S Casas et al.
LEUKEMIA & LYMPHOMA (2003)
Dimerization contributes to oncogenic activation of MLL chimeras in acute leukemias
CW So et al.
CANCER CELL (2003)
MLL repression domain interacts with histone deacetylases, the polycomb group proteins HPC2 and BMI-1, and the corepressor C-terminal-binding protein
ZB Xia et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Comparative analysis of MLL partial tandem duplication and FLT3 internal tandem duplication mutations in 956 adult patients with acute myeloid leukemia
C Steudel et al.
GENES CHROMOSOMES & CANCER (2003)
Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias:: dominance of HOX dysregulation
AA Ferrando et al.
BLOOD (2003)
The Paf1 complex is required for histone h3 methylation by COMPASS and Dot1p: Linking transcriptional elongation to histone methylation
NJ Krogan et al.
MOLECULAR CELL (2003)
Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization
JJD Hsieh et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation
T Nakamura et al.
MOLECULAR CELL (2002)
MLL targets SET domain methyltransferase activity to Hox gene promoters
TA Milne et al.
MOLECULAR CELL (2002)
Methylation of histone H3 by COMPASS requires ubiquitination of histone H2B by Rad6
J Dover et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast
ZW Sun et al.
NATURE (2002)
The MT domain of the proto-oncoprotein MLL binds to CpG-containing DNA and discriminates against methylation
M Birke et al.
NUCLEIC ACIDS RESEARCH (2002)
MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia
SA Armstrong et al.
NATURE GENETICS (2002)
Segmental amplification of 11q23 region identified by flourescence in situ hybridization in four patients with myeloid disorders: a review
KS Reddy et al.
CANCER GENETICS AND CYTOGENETICS (2001)
The Polycomb group - no longer an exclusive club?
HW Brock et al.
CURRENT OPINION IN GENETICS & DEVELOPMENT (2001)
MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein
P Ernst et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
Upregulation of Meis1 and HoxA9 in acute lymphocytic leukemias with the t(4:11) abnormality
T Rozovskaia et al.
ONCOGENE (2001)
The Atlas of Genetics and Cytogenetics in Oncology and Haematology on the Internet and a review on infant leukemias
JL Huret et al.
CANCER GENETICS AND CYTOGENETICS (2000)
Tumorigenesis in mice with a fusion of the leukaemia oncogene MII and the bacterial lacZ gene
CL Dobson et al.
EMBO JOURNAL (2000)
Chromatin-related properties of CBP fused to MLL generate a myelodysplastic-like syndrome that evolves into myeloid leukemia
C Lavau et al.
EMBO JOURNAL (2000)
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