期刊
ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE
卷 5, 期 -, 页码 51-75出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-pathol-121808-102113
关键词
evolution; cancer genome; DNA sequencing
类别
资金
- National Cancer Institute [CA 102029, CA 115802]
- U.S. Department of Defense [W81XWH-07-0029]
- National Institute of Aging [AG033485]
- National Cancer Institute/Health Research Board of Ireland Joint Research Fellowship
- NATIONAL CANCER INSTITUTE [R01CA102029, R01CA115802] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [F30AG033485] Funding Source: NIH RePORTER
Cancer recapitulates Darwinian evolution. Mutations acquired during life that provide cells with a growth or survival advantage will preferentially multiply to form a tumor. As a result of The Cancer Genome Atlas Project, we have gathered detailed information on the nucleotide sequence changes in a number of human cancers. The sources of mutations in cancer are diverse, and the complexity of those found to be clonally present in tumors has increasingly made it difficult to identify key rate-limiting genes for tumor growth that could serve as potential targets for directed therapies. The impact of DNA sequencing on future cancer research and personalized therapy is likely to be profound and merits critical evaluation.
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