期刊
ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE
卷 4, 期 -, 页码 461-487出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev.pathol.3.121806.151422
关键词
chromosomal instability; carcinogenesis; DNA repair; mitosis
类别
资金
- Medical Research Council
- The Wellcome Trust
- European Union
- Cancer Research UK
- The Breast Cancer Campaign
- MRC [MC_U105359877, G9900064, G0600332, G0700651] Funding Source: UKRI
- Medical Research Council [G9900064, MC_U105359877, G0600332, G0700651] Funding Source: researchfish
Single-gene disorders that predispose to cancer afford a unique window into the mechanisms of carcinogenesis. I argue that the instability in chromosome structure and number provoked by inactivation of the breast cancer-susceptibility genes BRCA1 and BRCA2 arises from the distinct functions served by their products in DNA repair or mitosis, explains many features of cancer pathogenesis in this setting, and has important implications for treatment. The chromosomal instability model proposed here suggests a conceptual framework for the connections between chromosomal aberrations and cancer.
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