期刊
ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE
卷 3, 期 -, 页码 587-613出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev.pathmechdis.3.121806.154300
关键词
regulated intramembranous proteolysis; transcriptional activation; expression profiling; mouse modeling; targeted therapy
类别
资金
- NATIONAL CANCER INSTITUTE [P01CA119070] Funding Source: NIH RePORTER
- NCI NIH HHS [P01 CA119070, P01 CA119070-02] Funding Source: Medline
Recent discoveries indicate that gain-of-function mutations in the Notch1 receptor are very common in human T cell acute lymphoblastic leukemia/lymphoma. This review discusses what these mutations have taught us about normal and pathophysiologic Notch1 signaling, and how these insights may lead to new targeted therapies for patients with this aggressive form of cancer.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据
分享论文
