期刊
ANNUAL REVIEW OF NUTRITION, VOL 34
卷 34, 期 -, 页码 95-116出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-nutr-071812-161215
关键词
intestine; liver; divalent metal-ion transporter 1; ferroportin 1; copper-transporting ATPase1; ceruloplasmin; hephaestin
资金
- NIDDK NIH HHS [R01 DK074867, 1R01 DK074867] Funding Source: Medline
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK074867] Funding Source: NIH RePORTER
Given their similar physiochemical properties, it is a logical postulate that iron and copper metabolism are intertwined. Indeed, iron-copper interactions were first documented over a century ago, but the homeostatic effects of one on the other has not been elucidated at a molecular level to date. Recent experimental work has, however, begun to provide mechanistic insight into how copper influences iron metabolism. During iron deficiency, elevated copper levels are observed in the intestinal mucosa, liver, and blood. Copper accumulation and/or redistribution within enterocytes may influence iron transport, and high hepatic copper may enhance biosynthesis of a circulating ferroxidase, which potentiates iron release from stores. Moreover, emerging evidence has documented direct effects of copper on the expression and activity of the iron-regulatory hormone hepcidin. This review summarizes current experimental work in this field, with a focus on molecular aspects of iron-copper interplay and how these interactions relate to various disease states.
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