期刊
ANNUAL REVIEW OF NUTRITION, VOL 33
卷 33, 期 -, 页码 205-229出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-nutr-071812-161240
关键词
O-GlcNAc transferase (OGT); O-GlcNAcase (OGA); uridine diphospho-N-acetylglucosamine (UDP-GlcNAc); hexosamine biosynthetic pathway (HBP)
资金
- Intramural NIH HHS [Z01 DK060101-01, ZIA DK060103-12] Funding Source: Medline
To maintain homeostasis under variable nutrient conditions, cells rapidly and robustly respond to fluctuations through adaptable signaling networks. Evidence suggests that the O-linked N-acetylglucosamine (O-GlcNAc) posttranslational modification of serine and threonine residues functions as a critical regulator of intracellular signaling cascades in response to nutrient changes. O-GlcNAc is a highly regulated, reversible modification poised to integrate metabolic signals and acts to influence many cellular processes, including cellular signaling, protein stability, and transcription. This review describes the role O-GlcNAc plays in governing both integrated cellular processes and the activity of individual proteins in response to nutrient levels. Moreover, we discuss the ways in which cellular changes in O-GlcNAc status may be linked to chronic diseases such as type 2 diabetes, neurodegeneration, and cancers, providing a unique window through which to identify and treat disease conditions.
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