期刊
ANNUAL REVIEW OF NUTRITION, VOL 32
卷 32, 期 -, 页码 183-+出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-nutr-072610-145159
关键词
systems biology; microbiome; prevention; mass spectrometry; personalized medicine; exposome
资金
- NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES [UL1TR000454] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [K24RR023356, UL1RR025008] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [P20HL113451, R21HL110044] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R21DK089369, U01DK069322] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [R01ES009047, P01ES016731, R01ES011195] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NURSING RESEARCH [R01NR012021] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG038746] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM [P50AA013757] Funding Source: NIH RePORTER
- NCATS NIH HHS [UL1 TR000454] Funding Source: Medline
- NCRR NIH HHS [UL1 RR025008, K24 RR023356, RR025008, RR023356] Funding Source: Medline
- NHLBI NIH HHS [HL110044, R21 HL110044, P20 HL113451] Funding Source: Medline
- NIAAA NIH HHS [P50 AA013757, AA013757] Funding Source: Medline
- NIA NIH HHS [AG038746, R01 AG038746] Funding Source: Medline
- NIDDK NIH HHS [U01 DK069322, DK069322, R21 DK089369, DK089369., DK089369] Funding Source: Medline
- NIEHS NIH HHS [R01 ES011195, ES016731, R01 ES009047, P01 ES016731, ES011195, ES009047] Funding Source: Medline
- NINR NIH HHS [NR012021, R01 NR012021] Funding Source: Medline
Nutritional metabolomics is rapidly maturing to use small-molecule chemical profiling to support integration of diet and nutrition in complex biosystems research. These developments are critical to facilitate transition of nutritional sciences from population-based to individual-based criteria for nutritional research, assessment, and management. This review addresses progress in making these approaches manageable for nutrition research. Important concept developments concerning the exposome, predictive health, and complex pathobiology serve to emphasize the central role of diet and nutrition in integrated biosystems models of health and disease. Improved analytic tools and databases for targeted and nontargeted metabolic profiling, along with bioinformatics, pathway mapping, and computational modeling, are now used for nutrition research on diet, metabolism, microbiome, and health associations. These new developments enable metabolome-wide association studies (MWAS) and provide a foundation for nutritional metabolomics, along with genomics, epigenomics, and health phenotyping, to support the integrated models required for personalized diet and nutrition forecasting.
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