期刊
ANNUAL REVIEW OF NUTRITION, VOL 31
卷 31, 期 -, 页码 177-201出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-nutr-072610-145133
关键词
proton-coupled folate transporter (PCFT) (SLC46A1); reduced folate carrier (RFC) (SLC19A1); hereditary folate malabsorption (HFM); cerebral folate deficiency (CFD); intestinal folate absorption; heme carrier protein-1 (HCP1)
资金
- NCI NIH HHS [R01 CA082621, CA82621] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA082621] Funding Source: NIH RePORTER
Until recently, the transport of folates into cells and across epithelia has been interpreted primarily within the context of two transporters with high affinity and specificity for folates, the reduced folate carrier and the folate receptors. However, there were discrepancies between the properties of these transporters and characteristics of folate transport in many tissues, most notably the intestinal absorption of folates, in terms of pH dependency and substrate specificity. With the recent cloning of the proton-coupled folate transporter (PCFT) and the demonstration that this transporter is mutated in hereditary folate malabsorption, an autosomal recessive disorder, the molecular basis for this low-pH transport activity is now understood. This review focuses on the properties of PUT and briefly addresses the two other folate-specific transporters along with other facilitative and ATP-binding cassette (ABC) transporters with folate transport activities. The role of these transporters in the vectorial transport of folates across epithelia is considered.
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