期刊
ANNUAL REVIEW OF NUTRITION
卷 28, 期 -, 页码 233-251出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev.nutr.28.061807.155530
关键词
insulin resistance; insulin receptor; insulin secretion; apoptosis; proliferation; gene expression; diabetes mellitus
资金
- Karolinska Institutet
- Swedish Research Council
- Novo Nordisk Foundation
- Swedish Diabetes Association
- Family Knut and Alice Wallenberg Foundation, Eurodia [FP6-518153]
- European Foundation for the Study of Diabetes
- Berth von Kantzow's Foundation
- Family Erling-Persson Foundation
- Diabetes Research Institute Foundation (Hollywood, FL)
The appropriate function of insulin-producing pancreatic beta-cells is crucial for the regulation of glucose homeostasis, and its impairment leads to diabetes mellitus, the most common metabolic disorder in man. In addition to glucose, the major nutrient factor, inputs from the nervous system, humoral components, and cell-cell communication within the islet of Langerhans act together to guarantee the release of appropriate amounts of insulin in response to changes in blood glucose levels. Data obtained within the past decade in several laboratories have revitalized controversy over the autocrine feedback action of secreted insulin on beta-cell function. Although insulin historically has been suggested to exert a negative effect on beta-cells, recent data provide evidence for a positive role of insulin in transcription, translation, ion flux, insulin secretion, proliferation, and beta-cell survival. Current insights on the role of insulin on pancreatic beta-cell function are discussed.
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