期刊
ANNUAL REVIEW OF NEUROSCIENCE, VOL 37
卷 37, 期 -, 页码 329-346出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-neuro-071013-013958
关键词
stomatogastric nervous system; central pattern generators; neuropeptides; biogenic amines; intrinsic excitability; synaptic strength
资金
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH046742, R37MH046742] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R37NS017813, R01NS017813] Funding Source: NIH RePORTER
- NIMH NIH HHS [MH 46742] Funding Source: Medline
- NINDS NIH HHS [NS 17813, R37 NS017813] Funding Source: Medline
Neuromodulation underliesmany behavioral states and has been extensively studied in small circuits. This has allowed the systematic exploration of how neuromodulatory substances and the neurons that release them can influence circuit function. The physiological state of a network and its level of activity can have profound effects on how the modulators act, a phenomenon known as state dependence. We provide insights from experiments and computational work that show how state dependence can arise and the consequences it can have for cellular and circuit function. These observations pose a general unsolved question that is relevant to all nervous systems: How is robust modulation achieved in spite of animal-to-animal variability and degenerate, nonlinear mechanisms for the production of neuronal and network activity?
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