期刊
ANNUAL REVIEW OF NEUROSCIENCE, VOL 36
卷 36, 期 -, 页码 519-546出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-neuro-062012-170412
关键词
mechanotransduction; hearing; touch; pain
资金
- BBSRC [BB/F000227/1] Funding Source: UKRI
- MRC [G0901905] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/F000227/1] Funding Source: researchfish
- Medical Research Council [G0901905] Funding Source: researchfish
- Wellcome Trust [101054/Z/13/Z] Funding Source: researchfish
- Arthritis Research UK [20200] Funding Source: Medline
- Biotechnology and Biological Sciences Research Council [BB/F000227/1] Funding Source: Medline
- Medical Research Council [G0901905] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
Transient receptor potential (TRP) channels act as sensors for a range of stimuli as diverse as light, sound, touch, pheromones, and tissue damage. Their role in mechanosensation in the animal kingdom, identified by gene ablation studies, has raised questions about whether they are directly mechanically gated, whether they act alone or in concert with other channels to transduce mechanical stimuli, and their relative importance in various functions and disease states in humans. The ability of these channels to form heteromultimers and interact with other ion channels underlies a range of cell-specific functions in different cell types. Here we overview recent advances in this rapidly expanding field, focusing on somatosensation, hearing, the cardiovascular system, and interactions between TRP channels and other proteins involved in mechanoelectrical signaling.
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