期刊
ANNUAL REVIEW OF NEUROSCIENCE, VOL 34
卷 34, 期 -, 页码 289-307出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-neuro-061010-113638
关键词
major depression; treatment-resistant depression; obsessive-compulsive disorder; tourette syndrome
资金
- NIMH NIH HHS [K23 MH077869] Funding Source: Medline
- NATIONAL INSTITUTE OF MENTAL HEALTH [K23MH077869] Funding Source: NIH RePORTER
Medications, psychotherapy, and other treatments are effective for many patients with psychiatric disorders. However, with currently available interventions, a substantial number of patients experience incomplete resolution of symptoms, and relapse rates are high. In the search for better treatments, increasing interest has focused on focal neuromodulation. This focus has been driven by improved neuroanatomical models of mood, thought, and behavior regulation, as well as by more advanced strategies for directly and focally altering neural activity. Deep brain stimulation (DBS) is one of the most invasive focal neuromodulation techniques available; data have supported its safety and efficacy in a number of movement disorders. Investigators have produced preliminary data on the safety and efficacy of DBS for several psychiatric disorders, as well. In this review, we describe the development and justification for testing DBS for various psychiatric disorders, carefully consider the available clinical data, and briefly discuss potential mechanisms of action.
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