期刊
ANNUAL REVIEW OF NEUROSCIENCE
卷 31, 期 -, 页码 339-358出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev.neuro.31.060407.125649
关键词
migration; polarity; axon guidance; dendrite; synapse formation
资金
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS047484] Funding Source: NIH RePORTER
- NINDS NIH HHS [R01 NS047484] Funding Source: Medline
The Wnt family of secreted proteins plays a crucial role in nervous system wiring. Writs regulate neuronal positioning, polarization, axon and dendrite development, and synaptogenesis. These diverse roles of Wnt proteins are due not only to the large numbers of Wnt ligands and receptors but also to their ability to signal through distinct signaling pathways in different cell types and developmental contexts. Studies oil Writs have shed new light on novel molecular mechanisms that control the development of complex neuronal connections. This review discusses recent advances on how Writ signaling influences different aspects of neuronal circuit assembly through changes in gene expression and/or cytoskeletal modulation.
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