期刊
ANNUAL REVIEW OF NEUROSCIENCE
卷 31, 期 -, 页码 151-173出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev.neuro.31.061307.090711
关键词
amyotrophic lateral sclerosis; motor neuron disease; Charcot-Marie-Tooth disease; Alzheimer's disease; Huntington's disease; Parkinson's disease
资金
- MRC [G0501573, G0401352, G0000749] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council Funding Source: Medline
- Medical Research Council [G0000749, G0501573, G0401352] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
Many major human neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS), display axonal pathologies including abnormal accumulations of proteins and organelles. Such pathologies highlight damage to the axon as part of the pathogenic process and, in particular, damage to transport of cargoes through axons. Indeed, we now know that disruption of axonal transport is an early and perhaps causative event in many of these diseases. Here, we review the role of axonal transport in neurodegenerative disease.
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