期刊
ANNUAL REVIEW OF MICROBIOLOGY, VOL 72
卷 72, 期 -, 页码 309-330出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-micro-090817-062257
关键词
glyoxylate shunt; isocitrate lyase; malate synthase; TCA cycle; isocitrate; acetate metabolism
资金
- Biotechnology and Biological Sciences Research Council Funding Source: Medline
- BBSRC [BB/R005435/1, BB/M019411/1] Funding Source: UKRI
2017 marks the 60th anniversary of Krebs' seminal paper on the glyoxylate shunt (and coincidentally, also the 80th anniversary of his discovery of the citric acid cycle). Sixty years on, we have witnessed substantial developments in our understanding of how flux is partitioned between the glyoxylate shunt and the oxidative decarboxylation steps of the citric acid cycle. The last decade has shown us that the beautifully elegant textbook mechanism that regulates carbon flux through the shunt in E. coli is an oversimplification of the situation in many other bacteria. The aim of this review is to assess how this new knowledge is impacting our understanding of flux control at the TCA cycle/glyoxylate shunt branch point in a wider range of genera, and to summarize recent findings implicating a role for the glyoxylate shunt in cellular functions other than metabolism.
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