期刊
ANNUAL REVIEW OF MICROBIOLOGY, VOL 68
卷 68, 期 -, 页码 137-154出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-micro-091213-112844
关键词
PASTA domains; LysM domains; metabolic quiescence; quorum sensing
类别
资金
- NIGMS NIH HHS [R01 GM83168] Funding Source: Medline
Peptidoglycan serves as a key structure of the bacterial cell by determining cell shape and providing resistance to internal turgor pressure. However, in addition to these essential and well-studied functions, bacterial signaling by peptidoglycan fragments, or muropeptides, has been demonstrated by recent work. Actively growing bacteria release muropeptides as a consequence of cell wall remodeling during elongation and division. Therefore, the presence of muropeptide synthesis is indicative of growth-promoting conditions and may serve as a broadly conserved signal for nongrowing cells to reinitiate growth. In addition, muropeptides serve as signals between bacteria and eukaryotic organisms during both pathogenic and symbiotic interactions. The increasingly appreciated role of the microbiota in metazoan organisms suggests that muropeptide signaling likely has important implications for homeostatic mammalian physiology.
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