期刊
ANNUAL REVIEW OF MICROBIOLOGY, VOL 67
卷 67, 期 -, 页码 417-435出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-micro-092412-155622
关键词
asymmetry; peptidoglycan; sporulation; aging; damage
类别
资金
- NIGMS NIH HHS [R01 GM051986, GM102841, GM051986, F32 GM083581, R01 GM102841, GM083581] Funding Source: Medline
Asymmetries in cell growth and division occur in eukaryotes and prokaryotes alike. Even seemingly simple and morphologically symmetric cell division processes belie inherent underlying asymmetries in the composition of the resulting daughter cells. We consider the types of asymmetry that arise in various bacterial cell growth and division processes, which include both conditionally activated mechanisms and constitutive, hardwired aspects of bacterial life histories. Although asymmetry disposes some cells to the deleterious effects of aging, it may also benefit populations by efficiently purging accumulated damage and rejuvenating newborn cells. Asymmetries may also generate phenotypic variation required for successful exploitation of variable environments, even when extrinsic changes outpace the capacity of cells to sense and respond to challenges. We propose specific experimental approaches to further develop our understanding of the prevalence and the ultimate importance of asymmetric bacterial growth.
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