期刊
TETRAHEDRON
卷 61, 期 47, 页码 11078-11106出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2005.09.030
关键词
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A total synthesis of zaragozic acid C by a convergent strategy is described in which the key features include (1) the simultaneous creation of the C4 and C5 quaternary stereogenic centers by a Sn(OTf)(2)-promoted aldol coupling reaction between an a-keto ester and a silyl ketene thioacetal derived from L- and D-tartaric acids, respectively, (2) the direct introduction of lithium acetylide as the Cl side chain equivalent onto the fully functionalized aldehyde, and (3) construction of the bicyclic core structure by acid-catalyzed internal ketalization under kinetically controlled conditions. (c) 2005 Elsevier Ltd. All rights reserved.
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