期刊
ANNUAL REVIEW OF MICROBIOLOGY, VOL 66
卷 66, 期 -, 页码 177-196出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-micro-092611-150203
关键词
Toll-like receptor; RIG-I-like receptor; NOD-like receptor; inflammasome; interferons
类别
资金
- NIAID NIH HHS [R01 AI064705, AI 062428, R56 AI062428, AI 054359, R01 AI081884, AI 064705, R01 AI054359, AI 081884, R01 AI062428, U54 AI057160] Funding Source: Medline
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R56AI062428, R01AI064705, R01AI081884, R01AI062428, U54AI057160, R01AI054359] Funding Source: NIH RePORTER
The innate immune system uses multiple strategies to detect viral infections. Because all viruses rely on host cells for their synthesis and propagation, the molecular features used to detect viral infections must be unique to viruses and absent from host cells. Research in the past decade has advanced our understanding of various cell-intrinsic and cell-extrinsic modes of virus recognition. This review examines the innate recognition from the point of view of virus invasion and replication strategies, and places innate sensors in the context of detecting viral genome, replication intermediate, transcriptional by-product, and other viral invasion strategies. On the basis of other unique features common to viral infections, undiscovered areas of virus detection are discussed.
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