期刊
ANNUAL REVIEW OF MICROBIOLOGY, VOL 65
卷 65, 期 -, 页码 129-147出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-micro-090110-102851
关键词
gram positive; pathogenesis; siderophore; heme; hemoglobin
类别
资金
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [U54AI057157, R01AI069233, F32AI091244, R01AI073843] Funding Source: NIH RePORTER
- NIAID NIH HHS [R01 AI073843, F32 AI091244, AI057157, R01 AI069233, AI073843, AI0169233, U54 AI057157, F32-AI091244-01] Funding Source: Medline
The unique redox potential of iron makes it an ideal cofactor in diverse biochemical reactions. Iron is therefore vital for the growth and proliferation of nearly all organisms, including pathogenic bacteria. Vertebrates sequester excess iron within proteins in order to alleviate toxicity and restrict the amount of free iron available for invading pathogens. Restricting the growth of infectious microorganisms by sequestering essential nutrients is referred to as nutritional immunity. In order to circumvent nutritional immunity, bacterial pathogens have evolved elegant systems that allow for the acquisition of iron during infection. The gram-positive extracellular pathogen Staphylococcus aureus is a commensal organism that can cause severe disease when it gains access to underlying tissues. Iron acquisition is required for S. aureus colonization and subsequent pathogenesis. Herein we review the strategies S. aureus employs to obtain iron through the production of siderophores and the consumption of host heme.
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