期刊
ANNUAL REVIEW OF MICROBIOLOGY, VOL 65
卷 65, 期 -, 页码 19-35出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-micro-090110-102934
关键词
oriC; pre-replicative complex; cell cycle; chromosome replication; initiator protein
类别
资金
- NIGMS NIH HHS [R01 GM54042, R01 GM054042] Funding Source: Medline
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM054042] Funding Source: NIH RePORTER
To ensure proper timing of chromosome duplication during the cell cycle, bacteria must carefully regulate the activity of initiator protein DnaA and its interactions with the unique replication origin oriC. Although several protein regulators of DnaA are known, recent evidence suggests that DnaA recognition sites, in multiple genomic locations, also play an important role in controlling assembly of pre-replicative complexes. In oriC, closely spaced high-and low-affinity recognition sites direct DnaA-DnaA interactions and couple complex assembly to the availability of active DnaA-ATP. Additional recognition sites at loci distant from oriC modulate DnaA-ATP availability by repressing new synthesis, recharging inactive DnaA-ATP, or titrating DnaA. Relying on genomic DnaA binding sites, as well as protein regulators, to control DnaA function appears to provide the best combination of high precision and dynamic regulation necessary to couple DNA replication with cell growth over a range of nutritional conditions.
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