期刊
ANNUAL REVIEW OF MICROBIOLOGY, VOL 64, 2010
卷 64, 期 -, 页码 143-162出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev.micro.112408.134309
关键词
MRSA; community-associated infections; Panton-Valentine leukocidin
类别
资金
- Intramural NIH HHS Funding Source: Medline
Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) strains are causing a severe pandemic of mainly skin and soft tissue and occasionally fatal infections The basis of their success is the combination of methicillin resistance at low fitness cost and high virulence Investigation of the virulence potential of CA-MRSA, a key prerequisite for the development of anti-CA-MRSA therapeutics, has focused on strain USA300, which is responsible for the most serious CA-MRSA epidemic seen in the United States Current data indicate that in this strain virulence evolved via increased expression of core-genome-encoded virulence determinants, such as alpha-toxin and phenol-soluble modulins, and acquisition of the phage-encoded Panton-Valentine leukocidin (PVL) genes All these toxins impact disease progression in animal models of USA300 infection In contrast, the basis of virulence in other CA-MRSA epidemics, v, Inch also include PVL-negative strains, is poorly understood
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据