期刊
ANNUAL REVIEW OF MICROBIOLOGY, VOL 64, 2010
卷 64, 期 -, 页码 475-493出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev.micro.112408.134123
关键词
foreign DNA resistance; adaptation; interference; genome typing; evolution
类别
Clustered regularly interspaced short palindromic repeats (CRISPRs) along with Cas proteins is a widespread system across bacteria and archaea that causes interference against foreign nucleic acids The CRISPR/Cas system acts in at least two general stages the adaptation stage, where the cell acquires new spacer sequences derived from foreign DNA, and the interference stage, which uses the recently acquired spacers to target and cleave invasive nucleic acid The CRISPR/Cas system participates in a constant evolutionary battle between phages and bacteria through addition or deletion of spacers in host cells and mutations or deletion in phage genomes This review describes the recent progress made in this fast-expanding field
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