期刊
ANNUAL REVIEW OF MICROBIOLOGY, VOL 64, 2010
卷 64, 期 -, 页码 277-292出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev.micro.091208.073614
关键词
mutator genes; competition; evolution; bacteriophage; life cycle; stationary phase
类别
资金
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [R01ES004889] Funding Source: NIH RePORTER
- NIEHS NIH HHS [ES04889] Funding Source: Medline
Extensive phenotypic and genomic diversity was detected among offspring of Salmonella enterica ssp enterica serovar Typhimurium LT2 (nonmutator) and LT7 (mutator, mutL) strains after decades of storage in sealed nutrient agar stabs In addition to numerous losses in carbon and nitrogen metabolism, the acquired new metabolites indicated that alternate pathways were established Particularly striking was the array of phage types when this phenotype was expected to be a stable feature. Evidence is presented regarding the role of mutator gene mud,in the establishment of diversity is well as the ability of cells to return to mutL genetic stabilization Mutations included deletions, duplications, frameshifts, inversions and transpositions In competition tests, survivors were more fit than were wild type Because survival strategies continue to intrigue microbiologists, observations are compared with those of others who have addressed related questions A brief genealogy of the archived strains is also recorded
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