期刊
ANNUAL REVIEW OF MICROBIOLOGY
卷 63, 期 -, 页码 27-44出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev.micro.091208.073514
关键词
repression; activation; autoregulation; protein-RNA interaction; RNA structure
类别
资金
- National Institutes of Health [GM52840, GM59969, GM66794]
RNA binding proteins are capable of regulating translation initiation by a variety of mechanisms. Although the vast majority of these regulatory mechanisms involve translational repression, one example of translational activation has been characterized in detail. The RNA recognition targets of these regulators, proteins exhibit a wide range in structural complexity, with some proteins recognizing complex pseudoknot structures and others binding to simple RNA hairpins and/or short repeated single-stranded sequences. In some instances the bound protein directly competes with ribosome binding, and in other instances the bound protein promotes formation of in RNA structure that inhibits ribosome binding. Examples also exist in which the bound protein traps the ribosome in a complex that is incapable of initiating translation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据