期刊
ANNUAL REVIEW OF MICROBIOLOGY
卷 63, 期 -, 页码 557-574出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev.micro.091208.073507
关键词
virulence; symbiosis; insect; immunity; toxins
类别
资金
- Leverhulme Trust
- BBSRC
- SFI
- Microbial Pathogenesis at Michigan State University
- USDA
- Biotechnology and Biological Sciences Research Council [BB/C008367/1] Funding Source: researchfish
Photorhabdus is a member of the family Enterobacteriaceae that lives in a mutualistic association with a Heterorhabditis nematode worm. The nematode worm burrows into insect prey and regurgitates Photohabdus, which goes on to kill the insect. The nematode feeds off the growing bacteria until the insect tissues are exhausted, whereupon they reassociate and leave the cadaver in search of new prey. This highly efficient partnership has been used for many years as a biological crop protection agent. The dual nature of Photorhabdus as a pathogen and mutualist makes it a superb model for understanding these apparently exclusive activities. Furthermore, recently identified clinical isolates of Photorhabdus helping us to understand how human pathogens can emerge from the enormous reservoir of invertebrate pathogens in the environment. As Photorhabdus has never been found outside a host animal, its niche represents an entirely biotic landscape. In this review we discuss what molecular adaptations allow this bacterium to complete this fascinating and complex life cycle.
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