期刊
ANNUAL REVIEW OF MICROBIOLOGY
卷 62, 期 -, 页码 425-443出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev.micro.62.081307.162758
关键词
Gag; MVBs; MDM; retrovirus; ESCRT
类别
资金
- National Institutes of Health [R01 AI 68463]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI068463] Funding Source: NIH RePORTER
HIV infection of macrophages is a critically important component of viral pathogenesis and progression to AIDS. Although the virus follows the same life cycle in macrophages and T lymphocytes, several aspects of the virus-host relationship are unique to macrophage infection. Examples of these are the long-term persistence of productive infection, sustained by the absence of cell death, and the ability of progeny virus to bud into and accumulate in endocytic compartments designated multivesicular bodies (MVBs). Recently, the hypothesis that viral exploitation of the macrophage endocytic machinery is responsible for perpetuating the chronic state of infection unique to this cell type has been challenged in several independent studies employing a variety of experimental strategies. This review examines the evidence supporting and refuting the canonical hypothesis and highlights recently identified cellular factors that may contribute to the unique aspects of the HIV-macrophage interaction.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据