期刊
JOURNAL OF NEUROSCIENCE
卷 25, 期 47, 页码 11045-11054出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.3652-05.2005
关键词
-
Stress responses in the adult rat are programmed early in life by maternal care and associated with epigenomic marking of the hippocampal exon I-7 glucocorticoid receptor ( GR) promoter. To examine whether such epigenetic programming is reversible in adult life, we centrally infused the adult offspring with the essential amino acid L-methionine, a precursor to S-adenosyl-methionine that serves as the donor of methyl groups for DNA methylation. Here we report that methionine infusion reverses the effect of maternal behavior on DNA methylation, nerve growth factor-inducible protein-A binding to the exon 17 promoter, GR expression, and hypothalamic-pituitary adrenal and behavioral responses to stress, suggesting a causal relationship among epigenomic state, GR expression, and stress responses in the adult offspring. These results demonstrate that, despite the inherent stability of the epigenomic marks established early in life through behavioral programming, they are potentially reversible in the adult brain.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据