期刊
ANNUAL REVIEW OF MEDICINE, VOL 65
卷 65, 期 -, 页码 63-79出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-med-060712-200152
关键词
genomics; mutations; rearrangements; pathways; cancer
DNA sequencing has taught us much about the structure of cancer genomes and enabled the discovery of novel genes that drive and maintain tumorigenesis. With the advent and application of next-generation massively parallel sequencing technologies, one can rapidly generate and analyze data from the cellular -omes: genomes, exomes, and transcriptomes. This review highlights recent genomic discoveries in signal transduction, metabolism, epigenetic modifications, cell cycle and genome maintenance, RNA processing, and transcription. Additionally, genomic sequencing has revealed the complexity of the cancer genome and has enabled the discovery of functional rearrangements with therapeutic and diagnostic potentials.
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