期刊
ANNUAL REVIEW OF MEDICINE, VOL 63
卷 63, 期 -, 页码 317-328出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-med-043010-144749
关键词
ER stress; unfolded protein response (UPR); neurodegenerative disease; liver disease; atherosclerosis; diabetes; cancer
资金
- NHLBI NIH HHS [R01 HL075662-09, P01 HL087123, P01 HL087123-05, R01 HL075662] Funding Source: Medline
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [P01HL087123, R01HL075662] Funding Source: NIH RePORTER
Perturbations in the normal functions of the endoplasmic reticulum (ER) trigger a signaling network that coordinates adaptive and apoptotic responses. There is accumulating evidence implicating prolonged ER stress in the development and progression of many diseases, including neurodegeneration, atherosclerosis, type 2 diabetes, liver disease, and cancer. With the improved understanding of the underlying molecular mechanisms, therapeutic interventions that target the ER stress response would be potential strategies to treat various diseases driven by prolonged ER stress.
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