期刊
ANNUAL REVIEW OF MEDICINE, VOL 63
卷 63, 期 -, 页码 131-145出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-med-062909-130018
关键词
HLA-B; HLA-C 3 ' UTR; genome-wide association study; cytotoxic T lymphocytes; microRNA
资金
- CCR NIH HHS [HHSN261200800001C] Funding Source: Medline
- Intramural NIH HHS Funding Source: Medline
- NCI NIH HHS [HHSN261200800001E] Funding Source: Medline
- NIAID NIH HHS [AI30914, R01 AI030914] Funding Source: Medline
Host genetic variation is presently estimated to account for about one-fourth of the observed differences in control of HIV across infected individuals. Genome-wide association studies have confirmed that polymorphism within the HLA class I locus is the primary host genetic contributor to determining outcome after infection. Here we progress beyond the genetic associations alone to consider the functional explanations for these correlations. In this process, the complex and multidimensional effects of HLA molecules in viral disease become apparent.
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