期刊
ANNUAL REVIEW OF MEDICINE, VOL 63
卷 63, 期 -, 页码 217-231出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-med-070910-083323
关键词
indocyanine green; molecular imaging; lymphatic imaging; cancer staging; hybrid nuclear and fluorescence imaging; cancer diagnostics
资金
- NATIONAL CANCER INSTITUTE [U54CA136404, R01CA128919] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL092923] Funding Source: NIH RePORTER
- NCI NIH HHS [R01 CA128919, U54 CA136404] Funding Source: Medline
- NHLBI NIH HHS [R01HL092923] Funding Source: Medline
Technical developments in near-infrared fluorescence (NIRF) imaging and tomography have enabled recent translation into investigational human studies. Noninvasive imaging of the lymphatic vasculature for diagnosis and assessment of function has been uniquely accomplished with NIR using indocyanine green (ICG), a nonspecific dye that has comparatively poor fluorescent properties compared to emerging dyes. Adjunct use of NIRF-ICG for (a) intraoperative sentinel lymph node mapping for cancer staging, (b) video-angiography during surgery, and (c) discrimination of malignant from benign breast lesions detected by mammography and ultrasongraphy also evidences the clinical utility of NIRF. Future NIRF imaging agents that consist of bright fluorescent dyes conjugated to disease-targeting moieties promise molecular imaging and image-guided surgery. In this review, emerging NIRF imaging is described within the context of nuclear imaging technologies that remain the gold standard of molecular imaging.
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